Trimitere la partea A din anexa la Regulamentul (UE) nr. 283/2013

Metode de testare (2)

Documente de orientare (3)

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WHO/FAO. 2002. Pesticide Specifications. Manual on development and use of FAO and WHO specifications for pesticides. Series FAO Plant Production and Protection Papers, Rome, 2002 (4)

EU Guidance Document on the assessment of the equivalence of technical materials of substances regulated under Regulation (EC) No. 1107/2009 (5) (SANCO/10597/2003 rev. 10.1)

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Method A.1 Melting/Freezing temperature (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 102: Melting Point/ Melting Range

Method A.2 Boiling temperature (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 103: Boiling point

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Method A.4 Vapour pressure (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 104: Vapour Pressure

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OECD Test Guideline 101: UV-VIS Absorption Spectra

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Method A.6 Water solubility (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 105: Water Solubility

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CIPAC Method MT 181: Solubility in organic solvents

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Method A.8 Partition coefficient (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 107: Partition coefficient, shake-flask method

Dacă un compus face parte din categoria substanțelor active de suprafață (astfel cum este definit de metoda A.5„tensiune superficială”), se poate aplica metoda agitării flaconului descrisă de metoda A.8 dacă din raport rezultă în mod clar că nu au apărut probleme (de exemplu, probleme de separare a fazelor). Metoda HPLC (cromatografie lichidă de înaltă performanță) descrisă de metoda A.8 nu se aplică compușilor activi de suprafață.

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OECD Test Guideline 112: Dissociation Constants in Water.

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Inflamabilitate:

Methods A.10 Flammability (solids), A.11 Flammability (gases), A.12 Flammability (contact with water) (Annex to Regulation (EC) No 440/2008), as appropriate;

Test N.1: test method for readily combustible solids (UN RTDG Manual of Tests and Criteria ST/SG/AC.10/11/Rev. 5 – Part III, section 33.2.1.4)

Autoîncălzire:

Methods A.15 Auto-ignition temperature (liquids and gases), A16 Relative self-ignition temperature for solids, (Annex to Regulation (EC) No 440/2008), as appropriate.

Test N.4: test method for self-heating substances (UN RTDG Manual of Tests and Criteria ST/SG/AC.10/11/Rev. 5 – Part III, section 33.3.1.6)

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Method A.9 Flash-point (Annex to Regulation (EC) No 440/2008) - only closed cup methods should be used.

Test methods according to table 2.6.3 of Annex I, Part 2 of Regulation (EC) No 1272/2008 (6) (liquids);

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Method A.14 Explosive properties (Annex to Regulation (EC) No 440/2008)

United Nations Recommendations on the Transport of Dangerous Goods (UN RTDG) Manual of Tests and Criteria ST/SG/AC.10/11/ Rev. 5 – Part I (Test series), section 11.

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Method A.5 Surface tension (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 115: Surface tension of aqueous solutions

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Solide: Method A.17 Oxidising properties (solids) (Annex to Regulation (EC) No 440/2008)

Lichide: Method A.21 Oxidising properties (liquids) (Annex to Regulation (EC) No 440/2008)

United Nations Recommendations on the Transport of Dangerous Goods (UN RTDG) Manual of Tests and Criteria ST/SG/AC.10/11/Rev. 4 – Part I (Test series).

Test O.1: Test for oxidizing solids (UN RTDG Manual of Tests and Criteria ST/SG/AC.10/11/Rev. 5 – Part III, section 34.4.1)

Test O.2: Test for oxidizing liquids (UN RTDG Manual of Tests and Criteria ST/SG/AC.10/11/Rev. 5 – Part III, section 34.4.2)

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Metodele de testare prezentate în partea II din anexa I la Regulamentul (CE) nr. 1272/2008

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EPPO standard series PP1: Efficacy evaluation of plant protection products (7)

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EPPO standard PP 1/213: Resistance risk analysis

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Material tehnic și preparate:

EU guidance document on analytical methods for the analysis of technical material and preparation (SANCO/3030/99 rev. 4)

Reziduuri:

EU guidance document on analytical methods for the determination of residues (Post-registration monitoring and control) (SANCO/825/00 rev. 8.1, 2010)

EU guidance document for generating and reporting methods of analysis in support of pre-registration data requirements (SANCO/3029/99 rev. 4).

OECD (2007). Guidance Document on Pesticide Residue Analytical Methods. Environment, Health and Safety Publications. Series on Testing and Assessment No. 72 and Series on Pesticides No. 39.

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EU Working Document. Draft Guidance for the Setting and Application of Acceptable Operator Exposure Levels (AOEL’s) (SANCO 7531 rev. 10, 10.07.2006)

OECD (2010) Guidance for the Derivation of an Acute Reference Dose” OECD Series on testing and assessment, No. 124, 08-Jun-2010

Method B.36 Toxicokinetics (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 417: Toxicokinetics

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Method B.36 Toxicokinetics (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 417: Toxicokinetics

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Method B.1 bis Acute oral toxicity - fixed dose procedure (Annex to Regulation (EC) No 440/2008).

Method B.1 tris Acute oral toxicity - Acute toxic class method (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 420: Acute oral toxicity: fixed dose procedure

OECD Test Guideline 423: Acute oral toxicity: acute toxic class method

OECD Test Guideline 425: Acute oral toxicity: up-and-down procedure

OECD Test Guideline No 401: Acute oral toxicity (only acceptable, if performed before December 2002)

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Method B.3 Acute toxicity (dermal) (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 402: Acute Dermal Toxicity

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Method B.2 Acute toxicity (inhalation) (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 403: Acute Inhalation Toxicity

OECD Test Guideline 436: Acute Inhalation Toxicity – Acute Toxic Class Method

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Method B.4 Acute toxicity: dermal irritation/corrosion (Annex to Regulation (EC) No 440/2008).

Method B.40 In vitro skin corrosion: transcutaneous electrical resistance test (TER) (Annex to Regulation (EC) No 440/2008).

Method B.40 bis In vitro skin corrosion: human skin model test (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 404: Acute Dermal Irritation/Corrosion

OECD Test Guideline 431: In vitro Skin Corrosion: Human Skin Model Test

OECD Test Guideline 430: In vitro Skin Corrosion: Transcutaneous Electrical Resistance Test

OECD Test Guideline 435: In vitro Membrane Barrier Test Method for Skin Corrosion

OECD Test Guideline 439: In vitro Skin Irritation: Reconstructed Human Epidermis Test Method

Method B.46 In vitro skin irritation: reconstructed human epidermis model test (Annex III of Regulation (EC) No 761/2009 (8)).

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Method B.5 Acute toxicity: eye irritation/corrosion (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 405: Acute eye irritation/corrosion

OECD Test Guideline 437: Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants

OECD Test Guideline 438: Isolated Chicken Eye Test Method for Identifying Ocular Corrosives and Severe Irritants

Method B.47 Bovine corneal opacity and permeability test method for identifying ocular corrosives and severe irritants (Annex of Regulation (EC) No 1152/2010 (9))

Method B.48 Isolated chicken eye test method for identifying ocular corrosives and severe irritants (Annex of Regulation (EC) No 1152/2010)

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Method B.42 Skin sensitisation: Local lymph node assay (Annex to Regulation (EC) No 440/2008).

Method B.6 Skin sensitisation (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 429: Skin Sensitisation – Local Lymph Node Assay

OECD Test Guideline 406: Skin sensitisation

OECD Test Guideline 442A: Skin Sensitisation – Local Lymph Node Assay: DA

OECD Test Guideline 442B: Skin Sensitisation – Local Lymph Node Assay: BrdU-ELISA

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Method B.41 In vitro 3T3 NRU phototoxicity test (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 432: In vitro 3T3 NRU Phototoxicity Test

OECD Test Guideline 101: UV-VIS Absorption Spectra

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Method B.7 Repeated dose (28 days) toxicity (oral) (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 407: Repeated dose 28-day oral toxicity study in rodents

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Method B.26 Sub-chronic oral toxicity test. Repeated dose 90-day oral toxicity study in rodents (Annex to Regulation (EC) No 440/2008).

Method B.27 Sub-chronic oral toxicity test. Repeated dose 90-day oral toxicity study in non-rodents (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 408: Repeated dose 90-day oral toxicity study in rodents

OECD Test Guideline 409: Repeated dose 90-day oral toxicity study in non-rodents

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Method B8 Repeated dose (28 days) toxicity (inhalation) (Annex to Regulation (EC) No 440/2008).

Method B.9 Repeated dose (28 days) toxicity (dermal) (Annex to Regulation (EC) No 440/2008).

Method B.28 Sub-chronic dermal toxicity test: 90-day repeated dermal dose study using rodent species (Annex to Regulation (EC) No 440/2008).

Method B.29 Sub-chronic inhalation toxicity study 90-day repeated inhalation dose study using rodent species (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 410: Repeated dose dermal toxicity: 21/28-day study.

OECD Test Guideline 411: Subchronic dermal toxicity: 90-day study.

OECD Test Guideline 412: Subacute inhalation toxicity: 28-day study.

OECD Test Guideline 413: Subchronic inhalation toxicity: 90-day study.

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Method B.13/14 Mutagenicity - reverse mutation test using bacteria (Annex to Regulation (EC) No 440/2008).

Method B.10 Mutagenicity - In vitro mammalian chromosome aberration test (Annex to Regulation (EC) No 440/2008).

Method B.17 – Mutagenicity – In vitro mammalian cell gene mutation test (Annex to Regulation (EC) No 440/2008). - For this test mouse lymphoma assay is recommended.

OECD Test Guideline 471: Bacterial Reverse Mutation Test

OECD Test Guideline 473: In vitro Mammalian Chromosome Aberration Test

OECD Test Guideline 476: In vitro Mammalian Cell Gene Mutation Test - For this test mouse lymphoma assay is recommended.

OECD Test Guideline 487. In vitro Mammalian Cell Micronucleus Test.

In vitro Comet assay could be used when justified.

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Method B.12 - Mutagenicity - In vivo mammalian erythrocyte micronucleus test (Annex to Regulation (EC) No 440/2008).

Method B.11 - Mutagenicity – In vivo mammalian bone-marrow chromosome aberration test (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 474: Mammalian Erythrocyte Micronucleus Test

OECD Test Guideline 475: Mammalian Bone Marrow Chromosome Aberration Test

OECD Test Guideline 486: Unscheduled DNA synthesis (UDS) - Test with mammalian liver cells in vivo.

OECD Test Guideline 488: Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays

Method B.39 Unscheduled DNA synthesis (UDS) - Test with mammalian liver cells in vivo (Annex to Regulation (EC) No 440/2008).

In vivo Comet assay could be used when justified and considering EFSA (2012). Minimum Criteria for the acceptance of in vivo alkaline Comet Assay Reports. EFSA Journal 2012;10(11):2977

Method B.23 Mammalian spermatogonial chromosome aberration test (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 483: Mammalian Spermatogonial Chromosome Aberration Test.

OECD Test Guideline 488: Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays.

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Method B.30 Chronic toxicity test (Annex to Regulation (EC) No 440/2008).

Method B.32 Carcinogenicity test (Annex to Regulation (EC) No 440/2008).

Method B.33 Combined chronic toxicity/carcinogenicity test (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 451: Carcinogenicity Studies.

OECD Test Guideline 452: Chronic Toxicity Studies.

OECD Test Guideline 453: Combined Chronic Toxicity/Carcinogenicity Studies.

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Method B.35 Two-generation reproduction toxicity study (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 416: Two-Generation Reproduction Toxicity.

OECD Test Guideline 443: Extended One-generation Reproduction Toxicity.

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Method B.31 Prenatal developmental toxicity study (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 414: Prenatal developmental toxicity study.

OECD Test Guideline 426: Developmental neurotoxicity study.

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Method B.43 Neurotoxicity study in rodents (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 424: Neurotoxicity study in rodents.

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Method B.37 Delayed neurotoxicity of organophosphorus substances after acute exposure (Annex to Regulation (EC) No 440/2008).

Method B.38 Delayed neurotoxicity of organophosphorus substances 28-day repeated dose study (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 418: Delayed Neurotoxicity of Organophosphorus Substances Following Acute Exposure.

OECD Test Guideline 419: Delayed Neurotoxicity of Organophosphorus Substances: 28-day Repeated Dose Study.

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EU Guidance document on the assessment of the relevance of metabolites in groundwater of substances regulated under Council Directive 91/414/EEC (SANCO/221/2000 – rev.10. final)

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OECD (2010) Guidance for conducting a single exposure toxicity study. IN: OECD (2010) Guidance for the Derivation of an Acute Reference Dose” OECD Series on testing and assessment, No. 124, 08-Jun-2010

OECD Test Guideline 456: H295R Steroidogenesis Assay

OECD Test Guideline 441: Hershberger Bioassay in Rats, A Short-term Screening Assay for (Anti)Androgenic Properties

OECD Test Guideline 455: Stably Transfected Human Estrogen Receptor-alpha Transcriptional Activation Assay for Detection of Estrogenic Agonist-Activity of Chemicals

OECD Test Guideline 440: Uterotrophic Bioassay in Rodents A short-term screening test for oestrogenic properties

OCSPP Guideline 890.1500: Pubertal Development and Thyroid Function in Intact Juvenile/Peripubertal Male Rats Assay

OCSPP Guideline 890.1450: Pubertal Development and Thyroid Function in Intact Juvenile/Peripubertal Female Rats Assay

U.S. Environmental Protection Agency (2007): 15-Day Intact Adult Male Rat Assay

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OECD (2009). Guidance Document on Overview of Residue Chemistry Studies (as revised in 2009). Environment, Health and Safety Publications. Series on Testing and Assessment No. 64 and Series on Pesticides No. 32.

OECD Test Guideline 506: Stability of pesticide residues in stored commodities

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OECD Test Guideline 501: Metabolism in crops

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OECD Test Guideline 503: Metabolism in livestock

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OECD Test Guideline 503: Metabolism in livestock

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OECD Test Guideline 503: Metabolism in livestock

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OECD Test Guideline 509: Crop field trials

OECD (2011) Guidance Document on Crop Field Trials (Series on Testing and Assessment No. 164 and Series on Pesticides No. 66)

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OECD Test Guideline 505: Residues in livestock.

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OECD Test Guideline 505: Residues in livestock.

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OECD Test Guideline 505: Residues in livestock.

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OECD Test Guideline 507: Nature of the pesticide residues in processed commodities – High temperature hydrolysis.

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OECD Test Guideline 508: Magnitude of the pesticide residues in processed commodities.

OECD Test Guideline 509: Crop field trials.

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OECD Test Guideline 508: Magnitude of the pesticide residues in processed commodities.

OECD (2008). Guidance document on magnitude of pesticide residues in processed commodities. Environment, Health and Safety Publications. Series on Testing and Assessment No. 96.

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OECD Test Guideline 502: Metabolism in rotational crops.

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OECD Test Guideline 504: Residues in rotational crops (limited field studies).

OECD Test Guideline 509: Crop field trials.

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OECD (2009). Guidance Document on the Definition of Residues. Environment, Health and Safety Publications. Series on Testing and Assessment No. 63 and Series on Pesticides No. 31

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EU guidance document "Guidelines on comparability, extrapolation, group tolerances and data requirements for setting MRLs" (SANCO 7525/VI/95 rev. 9, March 2011).

OECD MRL calculator (2011)

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EU guidance document "Guidelines on comparability, extrapolation, group tolerances and data requirements for setting MRLs" (SANCO 7525/VI/95 rev. 9, March 2011).

OECD MRL calculator (2011)

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EU guidance document "Calculation of Maximum Residue Levels and Safety Intervals e.g. Pre-harvest Intervals" (SANCO 7039/VI/95, 22/7/1997)

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EFSA calculation model Pesticide Residue Intake Model "PRIMo" - revision 2 (10)

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OECD Test Guideline 307: Aerobic and anaerobic transformation in soil.

ISO 10381-6:2009 Soil quality. Sampling. Guidance on the collection, handling and storage of soil under aerobic conditions for the assessment of microbiological processes, biomass and diversity in the laboratory

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OECD Test Guideline 307: Aerobic and anaerobic transformation in soil.

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OECD Test Guideline 307: Aerobic and anaerobic transformation in soil.

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SETAC 1995 – Procedures for assessing the environmental fate and ecotoxicity of pesticides

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EFSA (2010). EFSA Panel on Plant Protection Products; Guidance for evaluating laboratory and field dissipation studies to obtain DegT50 values of plant protection products in soil. EFSA Journal 2010;8(12):1936.

OECD Test Guideline 307: Aerobic and anaerobic transformation in soil.

FOCUS Ground Water

FOCUS Degradation Kinetics

EFSA (2007). Scientific Opinion on a request from EFSA related to the default Q10 value used to describe the temperature effect on transformation rates of pesticides in soil. The EFSA Journal (2007) 622, 1-32.

US EPA OCSPP 835.6100: Terrestrial field dissipation

FOCUS Ground Water

FOCUS Degradation Kinetics

FOCUS soil persistence models

Aspectele tehnice ale determinării ratei de degradare în sol în studiile de teren pot fi găsite în:

Regulatory Directive DIR2006-01: Harmonization of Guidance for Terrestrial Field Studies of Pesticide Dissipation under the North American Free Trade Agreement. Pest Management Regulatory Agency (PMRA). Health Canada (11)

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OECD Test Guideline 106: Adsorption - Desorption Using a Batch Equilibrium Method

OECD Test Guideline 121: Estimation of the Adsorption Coefficient (Koc ) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC)

OECD Test Guideline 307: Aerobic and anaerobic transformation in soil.

FOCUS Ground Water

European Commission. Scientific Committee on plants SCP/KOC/002-Final. Opinion of the Scientific Committee on Plants on methods for the determination of the organic carbon adsorption coefficient (K0c) for a plant protection product active substance in the context of Council Directive 91/414/EEC (18 July 2002) (12)

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FOCUS Ground Water

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OECD Test Guideline 312: Leaching in Soil Columns

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OECD Guidance Document 22: Guidance Document for the Performance Of Out-door Monolith Lysimeter Studies

FOCUS Ground Water

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FOCUS Ground Water

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OECD Test Guideline 111: Hydrolysis as a Function of pH

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OECD Test Guideline 316: Phototransformation of Chemicals in Water - Direct Photolysis

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Method C.4 Determination of "ready" biodegradability (Annex to Regulation (EC) No 440/2008).

OECD Guideline Test 301: Ready Biodegradability (301 A - F)

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OECD Test Guideline 309: Aerobic Mineralisation in Surface Water - Simulation Biodegradation Test

ECHA Guidance on information requirements and chemical safety assessment Chapter R 11: PBT Assessment

OECD Test Guideline 308: Aerobic and Anaerobic Transformation in Aquatic Sediment Systems

FOCUS Surface Water

FOCUS Degradation Kinetics

OECD Test Guideline 308: Aerobic and Anaerobic Transformation in Aquatic Sediment Systems

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FOCUS Air

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OECD series of testing and assessment Number 54. "Current approaches in the statistical analysis of ecotoxicity data: a guidance to application"

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EFSA (2009) Guidance of EFSA - Risk assessment for birds and mammals. EFSA Journal 2009; 7(12):1438.

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OECD Test Guideline No 223: Avian acute oral toxicity study

sau

US EPA OCSPP 850.2100: Avian oral toxicity test

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OECD Test Guideline 205: Avian Dietary Toxicity Test

sau

US EPA OCSPP 850.2200: Avian dietary toxicity test.

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OECD Test Guideline 206: Avian Reproduction Test

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US EPA OCSPP 850.2300: Avian Reproduction Test

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OECD Test Guideline 231: Amphibian Metamorphosis Assay

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Workshop report on OECD countries activities regarding testing, assessment and management of endocrine disrupters. Series on testing and assessment No 118. 18 January 2010.

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EU Guidance Document on Aquatic Ecotoxicology (SANCO/3268/2001 rev.4)

OECD (2000). Guidance document on aquatic toxicity testing of difficult substances and mixtures. OECD series on testing and assessment Number 23.

OECD Test Guideline 203: Fish, Acute Toxicity Test (13)

OECD. Series on testing and assessment No 126. Short guidance on the threshold approach for acute fish toxicity. ENV/JM/MONO(2010)17

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OECD Test Guideline 210: Fish, Early-Life Stage Toxicity Test

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US EPA protocol OCSPP 850.1500 Fish life cycle toxicity.

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OECD Test Guideline 229: Fish Short Term Reproduction Assay

OECD Test Guideline 230: 21-day Fish Assay: A Short-Term Screening for Oestrogenic and Androgenic Activity, and Aromatase Inhibition

OECD Test Guideline 231: Amphibian Metamorphosis Assay

OECD Test Guideline 234 Fish Sexual Development Test

Workshop report on OECD countries activities regarding testing, assessment and management of endocrine disrupters. Series on testing and assessment No 118. 18 January 2010.

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EU Guidance Document on Aquatic Ecotoxicology (SANCO/3268/2001 rev.4)

OECD Test Guideline 202: Daphnia sp. Acute Immobilisation Test

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US EPA OCSPP 850.1035 Mysid Acute Toxicity Test

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OECD Test Guideline 211: Daphnia magna Reproduction Test

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US EPA OCSPP 850.1350 Mysid Chronic Toxicity Test

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Orientarea 219 a OCDE privind testarea: Test de toxicitate la Chironomus într-un sistem apă îmbogățită – sediment [în general, un sistem apă îmbogățită - sediment (a se vedea OCDE 219) acoperă mai bine căile de expunere specifice produselor de protecție a plantelor]

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OECD Test Guideline 218: Sediment-Water Chironomid Toxicity Using Spiked Sediment

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OECD Test Guideline 201: Algae growth inhibition test

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OECD Test Guideline 201: Algae growth inhibition test.

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OECD Test Guideline 221: Lemna sp. Growth Inhibition Test

ASTM E1913-04: Standard Guide for Conducting Static, Axenic, 14-Day Phytotoxicity Tests in Test Tubes with the Submersed Aquatic Macrophyte, Myriophyllum sibiricum Komarov

Development of a proposed test method for the rooted aquatic macrophyte Myriophyllum sp. In: Maltby L, Arnold D, Arts G, et al (2010). Aquatic Macrophyte Risk Assessment for pesticides (AMRAP). SETAC Press & CRC Press, Taylor & -Francis Group, Boca Raton, London, New York, p. 46-56.

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EU Guidance Document on Aquatic Ecotoxicology (SANCO/3268/2001 rev.4)

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EU Guidance Document on Terrestrial Ecotoxicology (SANCO/10329/2002 rev 2)

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EPPO Standard PP 3/10 (3) Environmental risk assessment scheme for plant protection products. Chapter 10: honeybees.

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EPPO Standard PP1/170 (4): Test methods for evaluating the side-effects of plant protection products on honeybees.

OECD Test Guideline 213: Honeybees, Acute Oral Toxicity Test

EPPO Standard PP1/170 (4): Test methods for evaluating the side-effects of plant protection products on honeybees.

OECD Test Guideline 214: Honeybees, Acute Contact Toxicity Test

Aupinel et al (2007): A new larval in vitro rearing method to test effects of pesticides on honey bee brood. Redia XC: 87-90

Oomen PA, de Ruijter A and van der Steen J, 1992. Method for honeybee brood feeding tests with insect growth - regulating insecticides. Bulletin OEPP/EPPO Bulletin 22, 613-616.

Aupinel et al (2007): A new larval in vitro rearing method to test effects of pesticides on honey bee brood. Redia XC: 87-90

Oomen PA, de Ruijter A and van der Steen J, 1992. Method for honeybee brood feeding tests with insect growth - regulating insecticides. Bulletin OEPP/EPPO Bulletin 22, 613-616.

Candolfi et al (2001). Guidance Document on Regulatory Testing and Risk Assessment Procedures for Plant Protection Products With Non-Target Arthropods: From the Escort 2 Workshop (European Standard Characteristics of Non-Target Arthropod Regulatory Testing). SETAC press, pp 46. ISBN 1-880611-52-x.

M.P. Candolfi, S. Blümel, R. Forster et al. (2000): Guidelines to evaluate side-effects of plant protection products to non-target arthropods. IOBC, BART and EPPO Joint Initiative. ISBN: 92-9067-129-7.

M.P. Candolfi, S. Blümel, R. Forster et al. (2000): Guidelines to evaluate side-effects of plant protection products to non-target arthropods. IOBC, BART and EPPO Joint Initiative. ISBN: 92-9067-129-7

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EU Guidance Document on Terrestrial Ecotoxicology (SANCO/10329/2002 rev 2)

OECD Test Guideline 222: Earthworm Reproduction Test (Eisenia fetida/Eisenia andrei)

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Pentru Collembola:

OECD Test Guideline 232: Collembolan Reproduction Test in Soil

Pentru acarieni prădători:

OECD Test Guideline 226: Predatory mite (Hypoaspis (Geolaelaps) aculeifer) reproduction test in soil

OECD Test Guideline 216: Soil Microorganisms: Nitrogen Transformation Test

EU Guidance Document on Terrestrial Ecotoxicology (SANCO/10329/2002 rev 2)

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EU Guidance Document on Terrestrial Ecotoxicology (SANCO/10329/2002 rev 2)

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Apariția plantulelor și creșterea plantulelor:

OECD Test Guideline 208: Terrestrial Plant Test: Seedling Emergence and Seedling Growth Test

Testarea vigorii vegetative a plantelor terestre:

OECD Test Guideline 227: Terrestrial Plant Test: Vegetative Vigour Test

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EU Guidance Document on Terrestrial Ecotoxicology (SANCO/10329/2002 rev 2)

OECD Test Guideline 209: Activated Sludge, Respiration Inhibition Test

EU Guidance Document on Terrestrial Ecotoxicology (SANCO/10329/2002 rev 2)

EFSA (2011). Guidance of EFSA - Submission of scientific peer-reviewed open literature for the approval of pesticide active substances under Regulation (EC) No 1107/2009. EFSA Journal 2011; 9(2):209

ECHA Guidance on the application of the CLP criteria. Guidance to Regulation (EC) No 1272/2008 on classification, labelling and packaging (CLP) of substances and mixtures.