Trimitere la partea A din anexa la Regulamentul (UE) nr. 283/2013

Metode de testare (2)

Documente de orientare (3)

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WHO/FAO. 2002. Pesticide Specifications. Manual on development and use of FAO and WHO specifications for pesticides. Series FAO Plant Production and Protection Papers, Rome, 2002 (4)

EU Guidance Document on the assessment of the equivalence of technical materials of substances regulated under Regulation (EC) No. 1107/2009 (5) (SANCO/10597/2003 rev. 10.1)

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Method A.1 Melting/Freezing temperature (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 102: Melting Point/ Melting Range

Method A.2 Boiling temperature (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 103: Boiling point

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Method A.4 Vapour pressure (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 104: Vapour Pressure

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OECD Test Guideline 101: UV-VIS Absorption Spectra

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Method A.6 Water solubility (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 105: Water Solubility

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CIPAC Method MT 181: Solubility in organic solvents

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Method A.8 Partition coefficient (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 107: Partition coefficient, shake-flask method

Dacă un compus face parte din categoria substanțelor active de suprafață (astfel cum este definit de metoda A.5„tensiune superficială”), se poate aplica metoda agitării flaconului descrisă de metoda A.8 dacă din raport rezultă în mod clar că nu au apărut probleme (de exemplu, probleme de separare a fazelor). Metoda HPLC (cromatografie lichidă de înaltă performanță) descrisă de metoda A.8 nu se aplică compușilor activi de suprafață.

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OECD Test Guideline 112: Dissociation Constants in Water.

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Inflamabilitate:

Methods A.10 Flammability (solids), A.11 Flammability (gases), A.12 Flammability (contact with water) (Annex to Regulation (EC) No 440/2008), as appropriate;

Test N.1: test method for readily combustible solids (UN RTDG Manual of Tests and Criteria ST/SG/AC.10/11/Rev. 5 – Part III, section 33.2.1.4)

Autoîncălzire:

Methods A.15 Auto-ignition temperature (liquids and gases), A16 Relative self-ignition temperature for solids, (Annex to Regulation (EC) No 440/2008), as appropriate.

Test N.4: test method for self-heating substances (UN RTDG Manual of Tests and Criteria ST/SG/AC.10/11/Rev. 5 – Part III, section 33.3.1.6)

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Method A.9 Flash-point (Annex to Regulation (EC) No 440/2008) - only closed cup methods should be used.

Test methods according to table 2.6.3 of Annex I, Part 2 of Regulation (EC) No 1272/2008 (6) (liquids);

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Method A.14 Explosive properties (Annex to Regulation (EC) No 440/2008)

United Nations Recommendations on the Transport of Dangerous Goods (UN RTDG) Manual of Tests and Criteria ST/SG/AC.10/11/ Rev. 5 – Part I (Test series), section 11.

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Method A.5 Surface tension (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 115: Surface tension of aqueous solutions

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Solide: Method A.17 Oxidising properties (solids) (Annex to Regulation (EC) No 440/2008)

Lichide: Method A.21 Oxidising properties (liquids) (Annex to Regulation (EC) No 440/2008)

United Nations Recommendations on the Transport of Dangerous Goods (UN RTDG) Manual of Tests and Criteria ST/SG/AC.10/11/Rev. 4 – Part I (Test series).

Test O.1: Test for oxidizing solids (UN RTDG Manual of Tests and Criteria ST/SG/AC.10/11/Rev. 5 – Part III, section 34.4.1)

Test O.2: Test for oxidizing liquids (UN RTDG Manual of Tests and Criteria ST/SG/AC.10/11/Rev. 5 – Part III, section 34.4.2)

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Metodele de testare prezentate în partea II din anexa I la Regulamentul (CE) nr. 1272/2008

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EPPO standard series PP1: Efficacy evaluation of plant protection products (7)

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EPPO standard PP 1/213: Resistance risk analysis

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Material tehnic și preparate:

EU guidance document on analytical methods for the analysis of technical material and preparation (SANCO/3030/99 rev. 4)

Reziduuri:

EU guidance document on analytical methods for the determination of residues (Post-registration monitoring and control) (SANCO/825/00 rev. 8.1, 2010)

EU guidance document for generating and reporting methods of analysis in support of pre-registration data requirements (SANCO/3029/99 rev. 4).

OECD (2007). Guidance Document on Pesticide Residue Analytical Methods. Environment, Health and Safety Publications. Series on Testing and Assessment No. 72 and Series on Pesticides No. 39.

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EU Working Document. Draft Guidance for the Setting and Application of Acceptable Operator Exposure Levels (AOEL’s) (SANCO 7531 rev. 10, 10.07.2006)

OECD (2010) Guidance for the Derivation of an Acute Reference Dose” OECD Series on testing and assessment, No. 124, 08-Jun-2010

Method B.36 Toxicokinetics (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 417: Toxicokinetics

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Method B.36 Toxicokinetics (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 417: Toxicokinetics

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Method B.1 bis Acute oral toxicity - fixed dose procedure (Annex to Regulation (EC) No 440/2008).

Method B.1 tris Acute oral toxicity - Acute toxic class method (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 420: Acute oral toxicity: fixed dose procedure

OECD Test Guideline 423: Acute oral toxicity: acute toxic class method

OECD Test Guideline 425: Acute oral toxicity: up-and-down procedure

OECD Test Guideline No 401: Acute oral toxicity (only acceptable, if performed before December 2002)

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Method B.3 Acute toxicity (dermal) (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 402: Acute Dermal Toxicity

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Method B.2 Acute toxicity (inhalation) (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 403: Acute Inhalation Toxicity

OECD Test Guideline 436: Acute Inhalation Toxicity – Acute Toxic Class Method

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Method B.4 Acute toxicity: dermal irritation/corrosion (Annex to Regulation (EC) No 440/2008).

Method B.40 In vitro skin corrosion: transcutaneous electrical resistance test (TER) (Annex to Regulation (EC) No 440/2008).

Method B.40 bis In vitro skin corrosion: human skin model test (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 404: Acute Dermal Irritation/Corrosion

OECD Test Guideline 431: In vitro Skin Corrosion: Human Skin Model Test

OECD Test Guideline 430: In vitro Skin Corrosion: Transcutaneous Electrical Resistance Test

OECD Test Guideline 435: In vitro Membrane Barrier Test Method for Skin Corrosion

OECD Test Guideline 439: In vitro Skin Irritation: Reconstructed Human Epidermis Test Method

Method B.46 In vitro skin irritation: reconstructed human epidermis model test (Annex III of Regulation (EC) No 761/2009 (8)).

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Method B.5 Acute toxicity: eye irritation/corrosion (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 405: Acute eye irritation/corrosion

OECD Test Guideline 437: Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants

OECD Test Guideline 438: Isolated Chicken Eye Test Method for Identifying Ocular Corrosives and Severe Irritants

Method B.47 Bovine corneal opacity and permeability test method for identifying ocular corrosives and severe irritants (Annex of Regulation (EC) No 1152/2010 (9))

Method B.48 Isolated chicken eye test method for identifying ocular corrosives and severe irritants (Annex of Regulation (EC) No 1152/2010)

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Method B.42 Skin sensitisation: Local lymph node assay (Annex to Regulation (EC) No 440/2008).

Method B.6 Skin sensitisation (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 429: Skin Sensitisation – Local Lymph Node Assay

OECD Test Guideline 406: Skin sensitisation

OECD Test Guideline 442A: Skin Sensitisation – Local Lymph Node Assay: DA

OECD Test Guideline 442B: Skin Sensitisation – Local Lymph Node Assay: BrdU-ELISA

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Method B.41 In vitro 3T3 NRU phototoxicity test (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 432: In vitro 3T3 NRU Phototoxicity Test

OECD Test Guideline 101: UV-VIS Absorption Spectra

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Method B.7 Repeated dose (28 days) toxicity (oral) (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 407: Repeated dose 28-day oral toxicity study in rodents

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Method B.26 Sub-chronic oral toxicity test. Repeated dose 90-day oral toxicity study in rodents (Annex to Regulation (EC) No 440/2008).

Method B.27 Sub-chronic oral toxicity test. Repeated dose 90-day oral toxicity study in non-rodents (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 408: Repeated dose 90-day oral toxicity study in rodents

OECD Test Guideline 409: Repeated dose 90-day oral toxicity study in non-rodents

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Method B8 Repeated dose (28 days) toxicity (inhalation) (Annex to Regulation (EC) No 440/2008).

Method B.9 Repeated dose (28 days) toxicity (dermal) (Annex to Regulation (EC) No 440/2008).

Method B.28 Sub-chronic dermal toxicity test: 90-day repeated dermal dose study using rodent species (Annex to Regulation (EC) No 440/2008).

Method B.29 Sub-chronic inhalation toxicity study 90-day repeated inhalation dose study using rodent species (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 410: Repeated dose dermal toxicity: 21/28-day study.

OECD Test Guideline 411: Subchronic dermal toxicity: 90-day study.

OECD Test Guideline 412: Subacute inhalation toxicity: 28-day study.

OECD Test Guideline 413: Subchronic inhalation toxicity: 90-day study.

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Method B.13/14 Mutagenicity - reverse mutation test using bacteria (Annex to Regulation (EC) No 440/2008).

Method B.10 Mutagenicity - In vitro mammalian chromosome aberration test (Annex to Regulation (EC) No 440/2008).

Method B.17 – Mutagenicity – In vitro mammalian cell gene mutation test (Annex to Regulation (EC) No 440/2008). - For this test mouse lymphoma assay is recommended.

OECD Test Guideline 471: Bacterial Reverse Mutation Test

OECD Test Guideline 473: In vitro Mammalian Chromosome Aberration Test

OECD Test Guideline 476: In vitro Mammalian Cell Gene Mutation Test - For this test mouse lymphoma assay is recommended.

OECD Test Guideline 487. In vitro Mammalian Cell Micronucleus Test.

In vitro Comet assay could be used when justified.

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Method B.12 - Mutagenicity - In vivo mammalian erythrocyte micronucleus test (Annex to Regulation (EC) No 440/2008).

Method B.11 - Mutagenicity – In vivo mammalian bone-marrow chromosome aberration test (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 474: Mammalian Erythrocyte Micronucleus Test

OECD Test Guideline 475: Mammalian Bone Marrow Chromosome Aberration Test

OECD Test Guideline 486: Unscheduled DNA synthesis (UDS) - Test with mammalian liver cells in vivo.

OECD Test Guideline 488: Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays

Method B.39 Unscheduled DNA synthesis (UDS) - Test with mammalian liver cells in vivo (Annex to Regulation (EC) No 440/2008).

In vivo Comet assay could be used when justified and considering EFSA (2012). Minimum Criteria for the acceptance of in vivo alkaline Comet Assay Reports. EFSA Journal 2012;10(11):2977

Method B.23 Mammalian spermatogonial chromosome aberration test (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 483: Mammalian Spermatogonial Chromosome Aberration Test.

OECD Test Guideline 488: Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays.

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Method B.30 Chronic toxicity test (Annex to Regulation (EC) No 440/2008).

Method B.32 Carcinogenicity test (Annex to Regulation (EC) No 440/2008).

Method B.33 Combined chronic toxicity/carcinogenicity test (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 451: Carcinogenicity Studies.

OECD Test Guideline 452: Chronic Toxicity Studies.

OECD Test Guideline 453: Combined Chronic Toxicity/Carcinogenicity Studies.

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Method B.35 Two-generation reproduction toxicity study (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 416: Two-Generation Reproduction Toxicity.

OECD Test Guideline 443: Extended One-generation Reproduction Toxicity.

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Method B.31 Prenatal developmental toxicity study (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 414: Prenatal developmental toxicity study.

OECD Test Guideline 426: Developmental neurotoxicity study.

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Method B.43 Neurotoxicity study in rodents (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 424: Neurotoxicity study in rodents.

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Method B.37 Delayed neurotoxicity of organophosphorus substances after acute exposure (Annex to Regulation (EC) No 440/2008).

Method B.38 Delayed neurotoxicity of organophosphorus substances 28-day repeated dose study (Annex to Regulation (EC) No 440/2008).

OECD Test Guideline 418: Delayed Neurotoxicity of Organophosphorus Substances Following Acute Exposure.

OECD Test Guideline 419: Delayed Neurotoxicity of Organophosphorus Substances: 28-day Repeated Dose Study.

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EU Guidance document on the assessment of the relevance of metabolites in groundwater of substances regulated under Council Directive 91/414/EEC (SANCO/221/2000 – rev.10. final)

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OECD (2010) Guidance for conducting a single exposure toxicity study. IN: OECD (2010) Guidance for the Derivation of an Acute Reference Dose” OECD Series on testing and assessment, No. 124, 08-Jun-2010

OECD Test Guideline 456: H295R Steroidogenesis Assay

OECD Test Guideline 441: Hershberger Bioassay in Rats, A Short-term Screening Assay for (Anti)Androgenic Properties

OECD Test Guideline 455: Stably Transfected Human Estrogen Receptor-alpha Transcriptional Activation Assay for Detection of Estrogenic Agonist-Activity of Chemicals

OECD Test Guideline 440: Uterotrophic Bioassay in Rodents A short-term screening test for oestrogenic properties

OCSPP Guideline 890.1500: Pubertal Development and Thyroid Function in Intact Juvenile/Peripubertal Male Rats Assay

OCSPP Guideline 890.1450: Pubertal Development and Thyroid Function in Intact Juvenile/Peripubertal Female Rats Assay

U.S. Environmental Protection Agency (2007): 15-Day Intact Adult Male Rat Assay

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OECD (2009). Guidance Document on Overview of Residue Chemistry Studies (as revised in 2009). Environment, Health and Safety Publications. Series on Testing and Assessment No. 64 and Series on Pesticides No. 32.

OECD Test Guideline 506: Stability of pesticide residues in stored commodities

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OECD Test Guideline 501: Metabolism in crops

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OECD Test Guideline 503: Metabolism in livestock

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OECD Test Guideline 503: Metabolism in livestock

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OECD Test Guideline 503: Metabolism in livestock

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OECD Test Guideline 509: Crop field trials

OECD (2011) Guidance Document on Crop Field Trials (Series on Testing and Assessment No. 164 and Series on Pesticides No. 66)

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OECD Test Guideline 505: Residues in livestock.

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OECD Test Guideline 505: Residues in livestock.

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OECD Test Guideline 505: Residues in livestock.

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OECD Test Guideline 507: Nature of the pesticide residues in processed commodities – High temperature hydrolysis.

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OECD Test Guideline 508: Magnitude of the pesticide residues in processed commodities.

OECD Test Guideline 509: Crop field trials.

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OECD Test Guideline 508: Magnitude of the pesticide residues in processed commodities.

OECD (2008). Guidance document on magnitude of pesticide residues in processed commodities. Environment, Health and Safety Publications. Series on Testing and Assessment No. 96.

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OECD Test Guideline 502: Metabolism in rotational crops.

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OECD Test Guideline 504: Residues in rotational crops (limited field studies).

OECD Test Guideline 509: Crop field trials.

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OECD (2009). Guidance Document on the Definition of Residues. Environment, Health and Safety Publications. Series on Testing and Assessment No. 63 and Series on Pesticides No. 31

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EU guidance document "Guidelines on comparability, extrapolation, group tolerances and data requirements for setting MRLs" (SANCO 7525/VI/95 rev. 9, March 2011).

OECD MRL calculator (2011)

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EU guidance document "Guidelines on comparability, extrapolation, group tolerances and data requirements for setting MRLs" (SANCO 7525/VI/95 rev. 9, March 2011).

OECD MRL calculator (2011)

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EU guidance document "Calculation of Maximum Residue Levels and Safety Intervals e.g. Pre-harvest Intervals" (SANCO 7039/VI/95, 22/7/1997)

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EFSA calculation model Pesticide Residue Intake Model "PRIMo" - revision 2 (10)

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OECD Test Guideline 307: Aerobic and anaerobic transformation in soil.

ISO 10381-6:2009 Soil quality. Sampling. Guidance on the collection, handling and storage of soil under aerobic conditions for the assessment of microbiological processes, biomass and diversity in the laboratory

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OECD Test Guideline 307: Aerobic and anaerobic transformation in soil.

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OECD Test Guideline 307: Aerobic and anaerobic transformation in soil.

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SETAC 1995 – Procedures for assessing the environmental fate and ecotoxicity of pesticides

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EFSA (2010). EFSA Panel on Plant Protection Products; Guidance for evaluating laboratory and field dissipation studies to obtain DegT50 values of plant protection products in soil. EFSA Journal 2010;8(12):1936.

OECD Test Guideline 307: Aerobic and anaerobic transformation in soil.

FOCUS Ground Water

FOCUS Degradation Kinetics

EFSA (2007). Scientific Opinion on a request from EFSA related to the default Q10 value used to describe the temperature effect on transformation rates of pesticides in soil. The EFSA Journal (2007) 622, 1-32.

US EPA OCSPP 835.6100: Terrestrial field dissipation

FOCUS Ground Water

FOCUS Degradation Kinetics

FOCUS soil persistence models

Aspectele tehnice ale determinării ratei de degradare în sol în studiile de teren pot fi găsite în:

Regulatory Directive DIR2006-01: Harmonization of Guidance for Terrestrial Field Studies of Pesticide Dissipation under the North American Free Trade Agreement. Pest Management Regulatory Agency (PMRA). Health Canada (11)

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OECD Test Guideline 106: Adsorption - Desorption Using a Batch Equilibrium Method

OECD Test Guideline 121: Estimation of the Adsorption Coefficient (Koc ) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC)

OECD Test Guideline 307: Aerobic and anaerobic transformation in soil.

FOCUS Ground Water

European Commission. Scientific Committee on plants SCP/KOC/002-Final. Opinion of the Scientific Committee on Plants on methods for the determination of the organic carbon adsorption coefficient (K0c) for a plant protection product active substance in the context of Council Directive 91/414/EEC (18 July 2002) (12)

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FOCUS Ground Water

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OECD Test Guideline 312: Leaching in Soil Columns

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OECD Guidance Document 22: Guidance Document for the Performance Of Out-door Monolith Lysimeter Studies

FOCUS Ground Water

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FOCUS Ground Water

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OECD Test Guideline 111: Hydrolysis as a Function of pH

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OECD Test Guideline 316: Phototransformation of Chemicals in Water - Direct Photolysis

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Method C.4 Determination of "ready" biodegradability (Annex to Regulation (EC) No 440/2008).

OECD Guideline Test 301: Ready Biodegradability (301 A - F)

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OECD Test Guideline 309: Aerobic Mineralisation in Surface Water - Simulation Biodegradation Test

ECHA Guidance on information requirements and chemical safety assessment Chapter R 11: PBT Assessment

OECD Test Guideline 308: Aerobic and Anaerobic Transformation in Aquatic Sediment Systems

FOCUS Surface Water

FOCUS Degradation Kinetics

OECD Test Guideline 308: Aerobic and Anaerobic Transformation in Aquatic Sediment Systems

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FOCUS Air

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OECD series of testing and assessment Number 54. "Current approaches in the statistical analysis of ecotoxicity data: a guidance to application"

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EFSA (2009) Guidance of EFSA - Risk assessment for birds and mammals. EFSA Journal 2009; 7(12):1438.

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OECD Test Guideline No 223: Avian acute oral toxicity study

sau

US EPA OCSPP 850.2100: Avian oral toxicity test

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OECD Test Guideline 205: Avian Dietary Toxicity Test

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US EPA OCSPP 850.2200: Avian dietary toxicity test.

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OECD Test Guideline 206: Avian Reproduction Test

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US EPA OCSPP 850.2300: Avian Reproduction Test

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OECD Test Guideline 231: Amphibian Metamorphosis Assay

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Workshop report on OECD countries activities regarding testing, assessment and management of endocrine disrupters. Series on testing and assessment No 118. 18 January 2010.

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EU Guidance Document on Aquatic Ecotoxicology (SANCO/3268/2001 rev.4)

OECD (2000). Guidance document on aquatic toxicity testing of difficult substances and mixtures. OECD series on testing and assessment Number 23.

OECD Test Guideline 203: Fish, Acute Toxicity Test (13)

OECD. Series on testing and assessment No 126. Short guidance on the threshold approach for acute fish toxicity. ENV/JM/MONO(2010)17

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OECD Test Guideline 210: Fish, Early-Life Stage Toxicity Test

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US EPA protocol OCSPP 850.1500 Fish life cycle toxicity.

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OECD Test Guideline 229: Fish Short Term Reproduction Assay

OECD Test Guideline 230: 21-day Fish Assay: A Short-Term Screening for Oestrogenic and Androgenic Activity, and Aromatase Inhibition

OECD Test Guideline 231: Amphibian Metamorphosis Assay

OECD Test Guideline 234 Fish Sexual Development Test

Workshop report on OECD countries activities regarding testing, assessment and management of endocrine disrupters. Series on testing and assessment No 118. 18 January 2010.

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EU Guidance Document on Aquatic Ecotoxicology (SANCO/3268/2001 rev.4)

OECD Test Guideline 202: Daphnia sp. Acute Immobilisation Test

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US EPA OCSPP 850.1035 Mysid Acute Toxicity Test

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OECD Test Guideline 211: Daphnia magna Reproduction Test

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US EPA OCSPP 850.1350 Mysid Chronic Toxicity Test

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Orientarea 219 a OCDE privind testarea: Test de toxicitate la Chironomus într-un sistem apă îmbogățită – sediment [în general, un sistem apă îmbogățită - sediment (a se vedea OCDE 219) acoperă mai bine căile de expunere specifice produselor de protecție a plantelor]

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OECD Test Guideline 218: Sediment-Water Chironomid Toxicity Using Spiked Sediment

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OECD Test Guideline 201: Algae growth inhibition test

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OECD Test Guideline 201: Algae growth inhibition test.

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OECD Test Guideline 221: Lemna sp. Growth Inhibition Test

ASTM E1913-04: Standard Guide for Conducting Static, Axenic, 14-Day Phytotoxicity Tests in Test Tubes with the Submersed Aquatic Macrophyte, Myriophyllum sibiricum Komarov

Development of a proposed test method for the rooted aquatic macrophyte Myriophyllum sp. In: Maltby L, Arnold D, Arts G, et al (2010). Aquatic Macrophyte Risk Assessment for pesticides (AMRAP). SETAC Press & CRC Press, Taylor & -Francis Group, Boca Raton, London, New York, p. 46-56.

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EU Guidance Document on Aquatic Ecotoxicology (SANCO/3268/2001 rev.4)

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EU Guidance Document on Terrestrial Ecotoxicology (SANCO/10329/2002 rev 2)

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EPPO Standard PP 3/10 (3) Environmental risk assessment scheme for plant protection products. Chapter 10: honeybees.

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EPPO Standard PP1/170 (4): Test methods for evaluating the side-effects of plant protection products on honeybees.

OECD Test Guideline 213: Honeybees, Acute Oral Toxicity Test

EPPO Standard PP1/170 (4): Test methods for evaluating the side-effects of plant protection products on honeybees.

OECD Test Guideline 214: Honeybees, Acute Contact Toxicity Test

Aupinel et al (2007): A new larval in vitro rearing method to test effects of pesticides on honey bee brood. Redia XC: 87-90

Oomen PA, de Ruijter A and van der Steen J, 1992. Method for honeybee brood feeding tests with insect growth - regulating insecticides. Bulletin OEPP/EPPO Bulletin 22, 613-616.

Aupinel et al (2007): A new larval in vitro rearing method to test effects of pesticides on honey bee brood. Redia XC: 87-90

Oomen PA, de Ruijter A and van der Steen J, 1992. Method for honeybee brood feeding tests with insect growth - regulating insecticides. Bulletin OEPP/EPPO Bulletin 22, 613-616.

Candolfi et al (2001). Guidance Document on Regulatory Testing and Risk Assessment Procedures for Plant Protection Products With Non-Target Arthropods: From the Escort 2 Workshop (European Standard Characteristics of Non-Target Arthropod Regulatory Testing). SETAC press, pp 46. ISBN 1-880611-52-x.

M.P. Candolfi, S. Blümel, R. Forster et al. (2000): Guidelines to evaluate side-effects of plant protection products to non-target arthropods. IOBC, BART and EPPO Joint Initiative. ISBN: 92-9067-129-7.

M.P. Candolfi, S. Blümel, R. Forster et al. (2000): Guidelines to evaluate side-effects of plant protection products to non-target arthropods. IOBC, BART and EPPO Joint Initiative. ISBN: 92-9067-129-7

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EU Guidance Document on Terrestrial Ecotoxicology (SANCO/10329/2002 rev 2)

OECD Test Guideline 222: Earthworm Reproduction Test (Eisenia fetida/Eisenia andrei)

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Pentru Collembola:

OECD Test Guideline 232: Collembolan Reproduction Test in Soil

Pentru acarieni prădători:

OECD Test Guideline 226: Predatory mite (Hypoaspis (Geolaelaps) aculeifer) reproduction test in soil

OECD Test Guideline 216: Soil Microorganisms: Nitrogen Transformation Test

EU Guidance Document on Terrestrial Ecotoxicology (SANCO/10329/2002 rev 2)

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EU Guidance Document on Terrestrial Ecotoxicology (SANCO/10329/2002 rev 2)

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Apariția plantulelor și creșterea plantulelor:

OECD Test Guideline 208: Terrestrial Plant Test: Seedling Emergence and Seedling Growth Test

Testarea vigorii vegetative a plantelor terestre:

OECD Test Guideline 227: Terrestrial Plant Test: Vegetative Vigour Test

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EU Guidance Document on Terrestrial Ecotoxicology (SANCO/10329/2002 rev 2)

OECD Test Guideline 209: Activated Sludge, Respiration Inhibition Test

EU Guidance Document on Terrestrial Ecotoxicology (SANCO/10329/2002 rev 2)

EFSA (2011). Guidance of EFSA - Submission of scientific peer-reviewed open literature for the approval of pesticide active substances under Regulation (EC) No 1107/2009. EFSA Journal 2011; 9(2):209

ECHA Guidance on the application of the CLP criteria. Guidance to Regulation (EC) No 1272/2008 on classification, labelling and packaging (CLP) of substances and mixtures.

Trimitere la Partea A din anexa la Regulamentul (UE) nr. 284/2013

Metodele de testare (2)

Documente orientative (3)

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WHO/FAO. 2010. Manual on development and use of FAO and WHO specifications for pesticides. Second revision of the first edition. Rome, 2010. (4)

EU Guidance Document on the assessment of the equivalence of technical materials of substances regulated under Regulation (EC) No 1107/2009 (5) (SANCO/10597/2003 rev. 10.1)

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WHO/FAO. 2010. Manual on development and use of FAO and WHO specifications for pesticides. Second revision of the first edition. Rome, 2010

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Proprietăți explozive:

Method A.14 Explosive properties (Annex of Regulation (EC) No 440/2008).

United Nations Recommendations on the Transport of Dangerous Goods (UN RTDG) Manual of Tests and Criteria ST/SG/AC.10/11/Rev. 5 – Part I (Test series), section 11.

Proprietăți oxidante:

Solids: Method A.17 Oxidising properties (solids) (Annex of Regulation (EC) No 440/2008)

Liquids: Method A.21 Oxidising properties (liquids) (Annex of Regulation (EC) No 440/2008)

Test O.1: Test for oxidizing solids (UN RTDG Manual of Tests and Criteria ST/SG/AC.10/11/Rev. 5 – Part III, section 34.4.1)

Test O.2: Test for oxidizing liquids (UN RTDG Manual of Tests and Criteria ST/SG/AC.10/11/Rev. 5 – Part III, section 34.4.2)

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Inflamabilitatea:

Method A.9 Flash-point (liquids) (Annex of Regulation (EC) No 440/2008)

Methods A.10 Flammability (solids), A.11 Flammability (gases), A.12 Flammability (contact with water) (Annex of Regulation (EC) No 440/2008), as appropriate.

Test N.1: Test method for readily combustible solids (UN RTDG Manual of Tests and Criteria ST/SG/AC.10/11/Rev. 5 – Part III, section 33.2.1.4)

Autoîncălzirea;

Methods A.15 Auto-ignition temperature (liquids and gases) and A.16 Relative self-ignition temperature for solids (Annex of Regulation (EC) No 440/2008)

Test N.4: test method for self-heating substances (UN RTDG Manual of Tests and Criteria ST/SG/AC.10/11/Rev. 5 – Part III, section 33.3.1.6)

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CIPAC Method MT 75.3: Determination of pH values (revised method)

Preparate acide sau alcaline:

CIPAC Method MT 31: free acidity or alkalinity

CIPAC Method MT 191: Acidity or alkalinity of formulations

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Lichide newtoniene:

OECD Test Guideline 114

Lichide non-newtoniene:

CIPAC method MT 192: Viscosity of liquids by rotational viscosimetry or

OECD Test Guideline 114

Tensiunea superficială:

Method A.5 Surface tension (Annex of Regulation (EC) No 440/2008)

Method A.5 is written only for solutions in water however the principles contained in it can be used for other formulation types e.g. EC

sau

OECD Test Guideline 115

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Densitatea relativă:

Method A.3 Relative density (Annex of Regulation (EC) No 440/2008).

sau

OECD Test Guideline 109

Densitatea globală:

CIPAC method MT 186: Bulk density

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Stabilitatea:

CIPAC MT 46.3: Accelerated storage procedure (combined method)

Efectul temperaturii scăzute asupra preparatelor lichide:

CIPAC Method MT 39.3: Low temperature stability of liquid formulations

CropLife International, 2009. Technical Monograph No 17. Guidelines for Specifying the Shelf Life of Plant Protection Products.

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CIPAC Method MT 53.3: Evaluation of wettability, wetting of dispersible powders

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CIPAC Method MT 47.2 Determination of the foaming of suspension concentrates

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Suspensibilitatea:

CIPAC Method MT 184: Suspensibility of formulations forming suspensions on dilution with water

Spontaneitatea dispersiei:

CIPAC Method MT 160: Spontaneity of dispersion of suspension concentrates

sau

CIPAC Method MT 174: Dispersibility of water dispersible granules

Stabilitatea dispersiei:

CIPAC Method MT 180: Suspo-emulsions, dispersion stability

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CIPAC Method MT 41.1: Dilution stability of aqueous solutions

sau

CIPAC Method MT 179: Water soluble granules, degree of dissolution and solution stability

sau

CIPAC Method MT: Solution properties of ST formulations (6)

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Produse dispersabile în apă:

CIPAC Method MT 185: Wet sieve test

Distribuția granulometrică (pulberi):

CIPAC Method MT 187: Particle size analysis by laser diffraction

Granulometria nominală (granule):

CIPAC Method MT 170: Dry sieve analysis of water dispersible granules

CIPAC Method MT 187: Particle size analysis by laser diffraction

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CIPAC Method MT 171: Dustiness of granular products

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Aplicabilă pentru granule sau tablete:

CIPAC Method MT 178: Attrition resistance of granules

CIPAC Method MT 178.2: Attrition resistance of dispersible granules

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CIPAC Method MT 193: Friability of tablets

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CIPAC Method MT 36.3: Emulsion characteristics of emulsifiable concentrates, emulsion characteristics and re-emulsification properties

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Capacitatea de scurgere:

CIPAC Method MT 172.1: Flowability of granular preparations after accelerated storage under pressure

Capacitatea de deversare:

CIPAC Method MT 148: Pourability of suspension concentrates

CIPAC Method MT 148.1: Pourability of suspension concentrates, revised method

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ASTM E1518 – 05: Standard Practice for Evaluation of Physical Compatibility of Pesticides in Aqueous Tank Mixtures by the Dynamic Shaker Method

Distribuția:

CIPAC Method MT 175: Seed treatment formulations, liquid, determination of seed-seed uniformity of distribution

Aderența:

CIPAC Method MT 194: Adhesion to Treated Seed

sau

European Seed Association, 2011. Assessment of free floating dust and abrasion particles of treated seeds as a parameter of the quality of treated seeds: Heubach test. ESA STAT Dust Working Group. (7)

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Metodele de testare prezentate în partea II din anexa I la Regulamentul (CE) nr. 1272/2008 (8)

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EPPO Standard PP1/239: Dose expression of plant protection products

EPPO Standard PP1/240: Harmonized basic information for databases on plant protection products

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FAO. Guidelines for the packaging and storage of pesticides

Rezistența materialului de ambalaj la conținut:

CropLife International Technical Monograph No 17, 2nd Edition

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Materialul tehnic și preparatele:

EU guidance document on analytical methods for the analysis of technical material and preparation (SANCO/3030/99 rev. 4)

Reziduuri:

EU guidance document on analytical methods for the determination of residues (Post-registration monitoring and control) (SANCO/825/00 rev. 8.1, 2010)

EU guidance document for generating and reporting methods of analysis in support of pre-registration data requirements (SANCO/3029/99 rev. 4).

OECD (2007). Guidance Document on Pesticide Residue Analytical Methods. Environment, Health and Safety Publications. Series on Testing and Assessment No. 72 and Series on Pesticides No. 39.

EPPO standard series PP1 (9) (Efficacy evaluation of plant protection products)

EPPO standard series PP1 (9) (Efficacy evaluation of plant protection products)

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Seeds harvested from treated plants: ISTA Methods - International Rules for Seed Testing  (10)

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Method B.1 bis Acute oral toxicity - fixed dose procedure (Annex of Regulation (EC) No 440/2008).

Method B.1 tris Acute oral toxicity - Acute toxic class method (Annex of Regulation (EC) No 440/2008).

OECD Test Guideline 420: Acute oral toxicity: fixed dose procedure

OECD Test Guideline 423: Acute oral toxicity: acute toxic class method

OECD Test Guideline 425: Acute oral toxicity: up-and-down procedure

OECD Test Guideline 401: Acute oral toxicity (only acceptable, if performed before December 2002)

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Method B.3 Acute toxicity (dermal) (Annex of Regulation (EC) No 440/2008)

OECD Test Guideline 402: Acute Dermal Toxicity

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Method B.2 Acute toxicity (inhalation) (Annex of Regulation (EC) No 440/2008).

OECD Test Guideline 403: Acute Inhalation Toxicity

OECD Test Guideline 436: Acute Inhalation Toxicity – Acute Toxic Class Method

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Method B.4 Acute toxicity: dermal irritation/corrosion (Annex of Regulation (EC) No 440/2008).

Method B.40 In vitro skin corrosion: transcutaneous electrical resistance test (TER) (Annex of Regulation (EC) No 440/2008).

Method B.40 bis In vitro skin corrosion: human skin model test (Annex of Regulation (EC) No 440/2008).

OECD Test Guideline 404: Acute Dermal Irritation/Corrosion

OECD Test Guideline 431: In vitro Skin Corrosion: Human Skin Model Test

OECD Test Guideline 430: In vitro Skin Corrosion: Transcutaneous Electrical Resistance Test

OECD Test Guideline 435: In vitro Membrane Barrier Test Method for Skin Corrosion

Method B.46 In vitro skin irritation: reconstructed human epidermis model test (Annex of Regulation (EC) No 440/2008).

OECD Test Guideline 439: In vitro Skin Irritation: Reconstructed Human Epidermis Test Method

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Method B.5 Acute toxicity: eye irritation/corrosion (Annex of Regulation (EC) No 440/2008).

OECD Test Guideline 405: Acute eye irritation/corrosion

OECD Test Guideline 437: Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants

OECD Test Guideline 438: Isolated Chicken Eye Test Method for Identifying Ocular Corrosives and Severe Irritants

Method B.47 Bovine corneal opacity and permeability test method for identifying ocular corrosives and severe irritants (Annex of Regulation (EC) No 1152/2010 (11))

Method B.48 Isolated chicken eye test method for identifying ocular corrosives and severe irritants (Annex of Regulation (EC) No 1152/2010)

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Method B.42 Skin sensitisation: Local lymph node assay (Annex of Regulation (EC) No 440/2008).

Method B.6 Skin sensitisation (Annex of Regulation (EC) No 440/2008).

OECD Test Guideline 429: Skin Sensitisation – Local Lymph Node Assay

OECD Test Guideline 406: Skin sensitisation

OECD Test Guideline 442A: Skin Sensitisation – Local Lymph Node Assay: DA

OECD Test Guideline 442B: Skin Sensitisation – Local Lymph Node Assay: BrdU-ELISA

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OECD Guidance Document for the Conduct of Studies of Occupational Exposure to Pesticides During Agricultural Application, Series on Testing and Assessment No. 9, ECDE/GD(97)148.

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OECD Test Guideline 428: Skin absorption: in vitro method

OECD Test Guideline 427: Skin absorption: in vivo method

Method B.44 Skin absorption: in vivo method. (Annex of Regulation (EC) No 440/2008).

Method B.45 Skin absorption: in vitro method. (Annex of Regulation (EC) No 440/2008).

OECD Guidance notes on dermal absorption, Series on Testing and Assessment No. 156, ENV/JM/MONO (2011)36.

WHO, 2006. Environmental Health Criteria, 235. Dermal Absorption. (12)

EFSA Scientific Opinion of PPR Panel - Guidance on Dermal Absorption EFSA Journal 2012; 10 (4):2665.

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Metodele de testare menționate în secțiunea 6 din anexa la Regulamentul (UE) nr. 283/2013 (13) se aplică.

Documentele orientative menționate în secțiunea 6 din anexa la Regulamentul (UE) nr. 283/2013 se aplică.

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OECD Test Guideline 307: Aerobic and anaerobic transformation in soil.

ISO 10381-6:2009 Soil quality. Sampling. Guidance on the collection, handling and storage of soil under aerobic conditions for the assessment of microbiological processes, biomass and diversity in the laboratory

EFSA Panel on Plant Protection Products; Guidance for evaluating laboratory and field dissipation studies to obtain DegT50 values of plant protection products in soil. EFSA Journal 2010;8(12):1936.

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OECD Test Guideline 307: Aerobic and anaerobic transformation in soil.

FOCUS Ground Water

FOCUS Degradation Kinetics

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Aspectele tehnice pentru determinarea vitezelor de degradare în sol în studiile de teren pot fi găsite în:

EPA Fate, Transport and Transformation Test Guideline OCSPP 835.6100 Terrestrial Field Dissipation.

Regulatory Directive DIR2006-01: Harmonization of Guidance for Terrestrial Field Studies of Pesticide Dissipation under the North American Free Trade Agreement. Pest Management Regulatory Agency (PMRA). Health Canada (14)

FOCUS Ground Water

FOCUS Degradation Kinetics

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OECD Test Guideline 106: Adsorption - Desorption Using a Batch Equilibrium Method

OECD Test Guideline 121: Estimation of the Adsorption Coefficient (Koc ) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC)

OECD Test Guideline 312: Leaching in Soil Columns

OECD Test Guideline 307: Aerobic and anaerobic transformation in soil.

FOCUS Ground Water

OECD Guidance Document 22: Guidance Document for the Performance Of Out-door Monolith Lysimeter Studies

FOCUS Ground Water

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FOCUS Ground Water

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Orientări privind calculul PEC:

FOCUS soil persistence models

FOCUS Ground Water (source of crop canopy interception values for different crop growth stages).

Orientări privind parametrii de degradare și calculul PEC:

FOCUS Degradation Kinetics

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OECD Test Guideline 309: Aerobic Mineralisation in Surface Water - Simulation Biodegradation Test

ECHA Guidance on information requirements and chemical safety assessment Chapter R 11: PBT Assessment

OECD Test Guideline 308: Aerobic and Anaerobic Transformation in Aquatic Sediment Systems

FOCUS Surface Water

FOCUS Degradation Kinetics

OECD Test Guideline 308: Aerobic and Anaerobic Transformation in Aquatic Sediment Systems

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FOCUS Ground Water

FOCUS Degradation Kinetics

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Estimarea concentrațiilor în apele de suprafață și în sedimente

FOCUS Surface Water

FOCUS Degradation Kinetics

EU Guidance on aquatic ecotoxicology (SANCO/3268/2001 rev.4)

Reducerea nivelurilor de expunere și evaluarea de nivel superior la scara peisajului:

FOCUS Landscape and Mitigation

FOCUS Air

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FOCUS Air

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OECD series of testing and assessment Number 54. "Current approaches in the statistical analysis of ecotoxicity data: a guidance to application"

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EFSA (2009) Guidance of EFSA - Risk assessment for birds and mammals. EFSA Journal 2009; 7(12):1438.

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OECD Test Guideline 223: Avian Acute oral toxicity study

sau

US EPA OCSPP 850.2100: Avian Acute Oral Toxicity Test (15)

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OECD Test Guideline 231: Amphibian Metamorphosis Assay

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EU Guidance Document on Aquatic Ecotoxicology (SANCO/3268/2001 rev.4) (16)

Pești:

OECD Test Guideline 203: Fish, Acute Toxicity Test

Nevertebrate:

OECD Test Guideline 202: Daphnia sp. Acute Immobilisation Test

US EPA OCSPP 850.1035 Mysid Acute Toxicity Test

Alge și macrofite:

OECD Test Guideline 201: Freshwater Alga and Cyanobacteria, Growth Inhibition Test

OECD Test Guideline 221: Lemna sp. Growth Inhibition Test

ASTM E1913-04: Standard Guide for Conducting Static, Axenic, 14-Day Phytotoxicity Tests in Test Tubes with the Submersed Aquatic Macrophyte, Myriophyllum sibiricum Komarov

Development of a proposed test method for the rooted aquatic macrophyte Myriophyllum sp. In: Maltby L, Arnold D, Arts G,.et al (2010). Aquatic Macrophyte Risk Assessment for pesticides (AMRAP). SETAC Press & CRC Press, Taylor & Francis Group, Boca Raton, London, New York., p. 46-56

OECD. Series on testing and assessment No 126. Short guidance on the threshold approach for acute fish toxicity. ENV/JM/MONO(2010)17.

Pești:

OECD Test Guideline 229: Fish Short Term Reproduction Assay

OECD Test Guideline 230: 21-day Fish Assay: A Short-Term Screening for Oestrogenic and Androgenic Activity, and Aromatase Inhibition

OECD Test Guideline 210: Fish, Early-Life Stage Toxicity Test

OECD Test Guideline 234: Fish Sexual Development Test

US EPA protocol OCSPP 850.1500 Fish life cycle toxicity

Nevertebrate:

OECD Test Guideline 211: Daphnia magna Reproduction Test

US EPA OCSPP 850.1350 Mysid Chronic Toxicity Test

Organisme care trăiesc în sedimente:

OECD Test Guideline 218: Sediment-Water Chironomid Toxicity Using Spiked Sediment

OECD Test Guideline 219: Sediment-Water Chironomid Toxicity Using Spiked Water

[în general, un sistem apă îmbogățită - sediment (a se vedea OCDE 219) acoperă mai bine căile de expunere specifice pentru produsele de protecție a plantelor]

Alte recomandări pot fi găsite în:

Brock TCM, Alix A, Brown CD, et al (2009). Linking Aquatic Exposure and Effects: Risk Assessment of Pesticides (E-LINK). SETAC Press

Maltby L, Arnold D, Arts G, et al (2010). Aquatic Macrophyte Risk Assessment for pesticides (AMRAP). SETAC Press & CRC Press, Taylor & Francis Group, Boca Raton, London, New York

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EU Guidance Document on Aquatic Ecotoxicology (SANCO/3268/2001 rev.4)

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EU Guidance Document on Terrestrial Ecotoxicology (SANCO/10329/2002 rev 2)

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EPPO Standard PP 3/10 (3) Environmental Risk Assessment Scheme for Plant Protection Products - Chapter 10: honey bees

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EPPO Standard PP1/170 (4): Test methods for evaluating the side-effects of plant protection products on honeybees.

OECD Test Guideline 213: Honeybees, Acute Oral Toxicity Test

EPPO Standard PP1/170 (4): Test methods for evaluating the side-effects of plant protection products on honeybees.

OECD Test Guideline 214: Honeybees, Acute Contact Toxicity Test

Aupinel et al (2007): A new larval in vitro rearing method to test effects of pesticides on honey bee brood. Redia XC: 87-90

Oomen PA, de Ruijter A and van der Steen J, 1992. Method for honeybee brood feeding tests with insect growth - regulating insecticides. Bulletin OEPP/EPPO Bulletin 22, 613-616.

Aupinel P et al. (2007): A new larval in vitro rearing method to test effects of pesticides on honey bee brood. Redia XC: 87-90

EPPO Standard PP 3/10 (3) Environmental Risk Assessment Scheme for Plant Protection Products - Chapter 10: honey bees.

Oomen PA, de Ruijter A and van der Steen J, 1992. Method for honeybee brood feeding tests with insect growth - regulating insecticides. Bulletin OEPP/EPPO Bulletin 22, 613-616.

OECD Guidance Document 75 on the honeybee (Apis mellifera L) brood test under semi-field conditions

EPPO Standard PP1/170 (4): Test methods for evaluating the side-effects of plant protection products on honeybees.

EPPO Standard PP1/170 (4): Test methods for evaluating the side-effects of plant protection products on honeybees

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EU guidance document on terrestrial ecotoxicology (SANCO/10329/2002 rev 2).

Candolfi et al (2001). Guidance Document on Regulatory Testing and Risk Assessment Procedures for Plant Protection Products With Non-Target Arthropods: From the Escort 2 Workshop (European Standard Characteristics of Non-Target Arthropod Regulatory Testing). SETAC press, pp 46. ISBN 1-880611-52-x

M.P. Candolfi, S. Blümel, R. Forster et al. (2000): Guidelines to evaluate side-effects of plant protection products to non-target arthropods. IOBC, BART and EPPO Joint Initiative. ISBN: 92-9067-129-7.

M.P. Candolfi, S. Blümel, R. Forster et al. (2000): Guidelines to evaluate side-effects of plant protection products to non-target arthropods. IOBC, BART and EPPO Joint Initiative. ISBN: 92-9067-129-7.

Mead-Briggs, M.A., Moll, M., Grimm, et al (2010). An extended laboratory test for evaluating the effects of plant protection products on the parasitic wasp, Aphidius rhopalosiphi (Hymenoptera, Braconidae). BioControl 55:329-338.

M.P. Candolfi, S. Blümel, R. Forster et al. (2000): Guidelines to evaluate side-effects of plant protection products to non-target arthropods. IOBC, BART and EPPO Joint Initiative. ISBN: 92-9067-129-7.

M.P. Candolfi, S. Blümel, R. Forster et al. (2000): Guidelines to evaluate side-effects of plant protection products to non-target arthropods. IOBC, BART and EPPO Joint Initiative. ISBN: 92-9067-129-7.

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EU Guidance Document on Terrestrial Ecotoxicology (SANCO/10329/2002 rev 2)

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OECD Test Guideline 222: Earthworm Reproduction Test (Eisenia fetida/Eisenia andrei)

ISO 11268-3:1999: Soil quality – Effects of pollutants on earthworms – Part 3: Guidance on the determination of effects in field situations

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Pentru Collembola:

OECD Test Guideline 232: Collembolan Reproduction Test in Soil

Pentru acarieni prădători:

OECD Test Guideline 226: Predatory mite (Hypoaspis (Geolaelaps) aculeifer) reproduction test in soil

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OECD Test Guideline 216: Soil Microorganisms: Nitrogen Transformation Test

EU Guidance Document on Terrestrial Ecotoxicology (SANCO/10329/2002 rev 2)

EU Guidance Document on Terrestrial Ecotoxicology (SANCO/10329/2002 rev 2)

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Germinarea răsadurilor și creșterea răsadurilor:

OECD Test Guideline 208: Terrestrial Plant Test: Seedling Emergence and Seedling Growth Test

Testarea vigoarii vegetative a plantelor terestre:

OECD Test Guideline 227: Terrestrial Plant Test: Vegetative Vigour Test

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EU Guidance Document on Terrestrial Ecotoxicology (SANCO/10329/2002 rev 2)

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EFSA (2011). Guidance of EFSA - Submission of scientific peer-reviewed open literature for the approval of pesticide active substances under Regulation (EC) No 1107/2009. EFSA Journal 2011; 9(2):209

ECHA Guidance on the application of the CLP criteria. Guidance to Regulation (EC) No 1272/2008 on classification, labelling and packaging (CLP) of substances and mixtures.

Denumirea comercială

Denumirea sursei

Locul de exploatare

Amelbergabronnen

Amelberga

Mater

Bon-Val

Minval

Bavikhove

Bru

Bru

Chevron

Chaudfontaine

Thermale

Chaudfontaine

Chevron

Monastère

Chevron

Christianabronnen

Christiana

Gavere

Clémentine

Clémentine

Spixhe

Cristal Monopole

Cristal Monopole

Aarschot

Duke

Duke

Francorchamps

Gintsbergbronnen

Gintsberg

Scheldewindeke

Harre

Harre

Werbomont-Ferrières

Koningsbronnen

Koning

Brakel

Leberg

Leberg

Roosdal

Love my planet®

L’OR

Chevron

Ordal

Ordal

Ranst

Pouhon de Bande

Pouhon de Bande

Bande

San Benedetto

Geneviève

Genval

Spa

Marie-Henriette

Spa

Spa

Barisart

Spa

Spa

Reine

Spa

Sty

Sty

Céroux-Mousty

Sunco

Sunco

Ninove

Toep

Toep

Brakel

Top

Top

Brakel

1

Volette

Etalle

Val

Val

Boortmeerbeek

Valvert

Valvert

Etalle

Villers Monopole

Villers

Villers-le-Gambon

Denumirea comercială

Denumirea sursei

Locul de exploatare

Sembrancher

La Garde

Sembrancher / Switzerland

Denumirea comercială

Denumirea sursei

Locul de exploatare

Айс Бред

(Ice Breath)

Драгойново сондаж 9

(Dragoynovo sondazh 9)

Драгойново

(Dragoynovo)

Банкя

(Bankia)

Банкя сондаж 1 хг Иваняне

(Bankya sondazh 1 hg Ivanyane)

Банкя

(Bankya)

Вега

(Vega)

Шивачево извор Хаджи Димитър

(Shivachevo izvor Hadzhi Dimitar)

Шивачево

(Shivachevo)

Велин

(Velin)

Велинград сондаж 5 Горски пункт

(Velingrad sondazh 5 Gorski punkt)

Велинград

(Velingrad)

Водица

(Voditza)

Водица сондаж Р-2

(Voditsa sondazh R-2)

Водица

(Voditsa)

Горна баня

(Gorna bania)

Горна баня сондаж 3

(Gorna banya sondazh 3)

Горна баня

(Gorna banya)

Горна баня

(Gorna bania)

Горна баня сондаж 4 и извор Домус дере

(Gorna banya sondazh 4 i izvor Domus dere)

Горна баня

(Gorna banya)

Девин

(Devin)

Девин сондаж 5

(Devin sondazh 5)

Девин

(Devin)

Девин газирана

(Devin gazirana)

Девин сондаж 3

(Devin sondazh 3)

Девин

(Devin)

Долна баня

(Dolna bania)

Долна баня сондаж 141

(Dolna banya sondazh 141)

Долна баня

(Dolna banya)

Долче Вита

(Dolce Vita)

Шивачево извор Хаджи Димитър

(Shivachevo izvor Hadzhi Dimitar)

Шивачево

(Shivachevo)

Извор

(Izvor)

Каварна сондаж Р-113

(Kavarna sondazh R-113)

Каварна

(Kavarna)

Княжево

(Kniajevo)

Княжево сондаж 1 хг

(Knyazhevo sondazh 1 hg)

Княжево

(Knyazhevo)

Княжевска

(Knyazhevska)

Княжево сондаж Книжна фабрика

(Knyazhevo sondazh Knizhna fabrika)

Княжево

(Knyazhevo)

Ком

(Kom)

Бързия сондаж 1

(Barzia sondazh 1)

Бързия

(Barzia)

Леново

(Lenovo)

Леново сондаж 12

(Lenovo sondazh 12)

Леново

(Lenovo)

Михалково

(Mihalkovo)

Михалково сондажи 1аВП и 1 ВКП

(Mihalkovo sondazhi 1aVP i 1 VKP)

Михалково

(Mihalkovo)

Пирин Спринг

(Pirin Spring)

Баничан сондаж 273

(Banichan sondazh 273)

Баничан

(Banichan)

Преподобна Стойна

(Prepodobna Stoyna)

Катунци сондаж 236 Разсадника

(Katuntsi sondazh 236 Razsadnika)

Катунци

(Katuntsi)

Ракитово

(Rakitovo)

Ракитово сондаж 5

(Rakitovo sondazh 5)

Ракитово

(Rakitovo)

Спанчевци

(Spanchevtsi)

Спанчевци сондаж 2

(Spanchevtsi sondazh 2)

Спанчевци

(Spanchevtsi)

Старо Железаре

(Staro Jelezare)

Старо Железаре сондажи 2 и 4

(Staro Zhelezare sondazhi 2 i 4)

Старо Железаре

(Staro Zhelezare)

Хисар

(Hisar)

Хисаря сондажи 1 и 7

(Hisarya sondazhi 1 i 7)

Хисаря

(Hisarya)

Хисар

(Hissar)

Хисаря извор Чобан чешма

(Hisarya izvor Choban cheshma)

Хисаря

(Hisarya)

Хисаря

(Hissaria)

Хисаря сондаж 7

(Hisarya sondazh 7)

Хисаря

(Hisarya)

Denumirea comercială

Denumirea sursei

Locul de exploatare

Mattoni

Mattoni

Kyselka u Karlových Varů

Magnesia

Magnesia

Mnichov u Mariánských Lázní

Ondrášovka

Ondrášovka

Ondrášov

Poděbradka

Poděbradka

Poděbrady - Velké Zboží

IL SANO

IL SANO

Chodová Planá

Aqua Maria

Aqua Maria

Mariánské Lázně

Hanácká kyselka

Hanácká kyselka

Horní Moštěnice

Mostini

Mostini

Brodek u Přerova

Korunní

Korunní

Stráž nad Ohří

Dobrá voda

Dobrá voda

Byňov

Denumirea comercială

Denumirea sursei

Locul de exploatare

Aqua d'or

Aqua d'or-kilden

Fasterholt, 7330 Brande

Denice

Denicekilden

Fasterholt, 7330 Brande

Carlsberg Kurvand

Arnakke Kilde

Silkeborg Bad, Silkeborg

Harrild

Harrilds Kilde

Harrildgård, 7330 Brande

Kærspringeren

Vinten-Kilden

Brønsholmvej 11, Vinten, Horsens

Iskilde

Iskilden

Skårdal, Langkær 29, Hem, 8660 Skanderborg

AQUA-WELL

AQUA-WELL-Kilden

Harboes Bryggeri, Spegerborgvej 32-34, 4230 Skælskør

Egekilde

Egekilde

Faxe Bryggeri A/S, Faxe Allé 1, 4640 Fakse

Kildevæld

Kildevæld

Sdr. Saltumvej 4, 9493, Saltum

Nornir

Nornir

Skerrisvej 4, 7330 Brande

Krusmølle Kilde

Krusmølle Kilde

Krusmølle Kilden, V/ Krusmølle i Sdr. Jylland

Holk

Holk

Amtsvejen 133, Mellerup, 8900 Randers / Århus

Denumirea comercială

Denumirea sursei

Locul de exploatare

1-Aqua-Quelle

1-Aqua-Quelle

Thür

Abenstaler Quelle

Abenstaler Quelle

Elsendorf-Hornegg

Achalmquelle

Quelle 29

Reutlingen-Rommelsbach

Adelheidquelle

Adelheidquelle

Bad Überkingen

Adelholzener Alpenquell Bergen

Adelholzener Alpenquell Bergen

Bad Adelholzen

Adelholzener Primus-Quelle

Adelholzener Primus-Quelle

Bad Adelholzen

Adelindis-Quelle

Adelindis-Quelle

Bad Buchau

Adello

Adello

Bad Liebenwerda

Adello

Brunnen XVII

Ebersburg-Weyhers

Gemarkung Lütter

Gemarkung Ebersberg

Ahrtalquelle

Ahrtalquelle

Sinzig

Aktisa

Aktisa-Brunnen

Bad Vilbel

Alasia Perle

Alasia Perle

Bad Liebenwerda

Alasia Perle

Alasia Perle (Alaska)

Bohrbrunnen II, Bohrbrunnen IV, Bohrbrunnen XIII, Bohrbrunnen XVI und Bohrbrunnen XIX

Ebersburg-Weyhers

Gemeinde Ebersburg

Gemarkung Weyhers

Gemarkung Lütter

Gemarkung Ebersberg

Albertusquelle

Albertusquelle

Dasing

Albertus-Quelle

Albertus-Quelle (II)

Dasing

Alete Mineralquelle

Alete Mineralquelle

Polling-Weiding/Kreis Mühldorf am Inn

Alexander-Quelle

Alexander-Quelle

Eppelborn

ALLGÄUER ALPENWASSER

Allgäuer Alpenwasser

Brunnen B2

Oberstaufen, Flur Nr. 304 – Gemarkung Thalkirchdorf

Allgäu-Quelle

Allgäu-Quelle

Oberstaufen-Thalkirchdorf

Aloisius Quelle

Aloisius Quelle

Gundelfingen an der Donau

Alosa

Tiefenquelle

Wagenfeld

Alosa

Tieflandquelle

Stralsund

Alstertaler Mineralbrunnen

Alstertaler Mineralbrunnen

Norderstedt

Alter Brunnen

Alter Brunnen

Bad Camberg-Oberselters

Altmühltaler Quelle

Altmühltaler Quelle

Treuchtlingen

Alvara-Quelle

Alvara-Quelle

Mendig

alwa

Alwaris-Quelle

Sachsenheim-Spielberg

alwa

alwa-Quelle

Sersheim

Alwa

bonalwa

Bad Peterstal-Griesbach

Amadeus-Quelle

Amadeus-Quelle (Brunnen 2)

Mönchengladbach

Ambassador

Ambassador

Bad Liebenwerda

Andreasquelle

Andreasquelle

Sulzbach am Main-Soden

Anhaltiner Bergquelle

Anhaltiner Bergquelle

Hecklingen-Gänsefurth

Ansgar-Quelle

Ansgar-Quelle

Rantum/Sylt

Apodis

Apodis Quelle

Emsdetten

Apollinaris

Apollinaris

Bad Neuenahr-Ahrweiler

Apollinaris Silence

Apollinaris Silence

Bad Neuenahr-Ahrweiler

Aqua Culinaris

Quintus-Quelle

Bruchsal

Aqua Fun

Elfen-Quelle

Haigerloch-Bad Imnau

Aqua Fun

Gebirgsquelle

Rhens

Aqua Nordic

Aqua Nordic

Husum-Rosendahl

Aqua Römer sanft

Sanft Quelle

Großerlach

Aqua Sirona

Aqua Sirona

Schwollen

Aqua Star

Brunnen XX

Ebersburg-Weyhers

Gemarkung Lütter

Gemarkung Ebersberg

Aqua-frisch

Heinberg-Quelle

Warburg-Germete

aquamono

Thalfanger Sprudel

Thalfang

davon abweichend Quellort: Malborn

Aquana

Aquana

Löningen

AQUANT

AQUANT

Gemarkung Fallingbostel

Aquarissima

Gebirgsquelle

Rhens

AquaRömer

Römerquelle

Mainhardt-Baad

AquaStar

AquaStar

Friedberg-Dorheim

Aquatiore

Fiorelino

Erftstadt

Aquella

Aquella

Bochum

Aquintéll

Aquintéll

Duisburg

Aquintéll

Aquintéll Quelle

Wagenfeld

Aquintéll Quelle

Aquintéll Quelle

Bad Brückenau

Aquintus

Aquintus Quelle

Duisburg-Walsum

Ardey Quelle

Ardey Quelle

Duisburg-Walsum

Ardey-Quelle

Ardey-Quelle

Dortmund

Arienheller

Arienheller

Rheinbrohl-Arienheller

Arienheller-Brunnen

Arienheller-Quelle

Rheinbrohl-Arienheller

Ariston-Sprudel

Ariston-Sprudel

Mendig

Ariwa

David-Quelle

Bad Peterstal

Ariwa

Paulusquelle

Bad Rippoldsau

Arkia Mineralwasser

Ried-Quelle

Bad Vilbel

Arkona Quelle

Arkona Quelle

Güstrow

Arnoldi Quelle

Arnoldi Quelle

Warburg-Germete

Arolser "Schloßbrunnen"

Arolser "Schloßbrunnen"

Arolsen

ARRET

Arret-Quelle

Bad Hönningen

Artesia-Quelle

Artesia-Quelle

Reuth bei Erbendorf

ASS

Scharmühlquelle

Bad Vilbel-Gronau

Assindia

Assindia Brunnen 12

Bochum

ASSINDIA

Assindia-Quelle

Haan

Assindia-Mineralwasser

Assindia Quelle

Essen-Kray

Astra

Astra

Bad Vilbel

Auburg-Quelle

Auburg-Quelle

Wagenfeld

Auenwald

St. Cyriakus-Quelle

Wöpse

Augusta-Victoria-Quelle

Augusta-Victoria-Quelle

Löhnberg-Selters

Autenrieder Schloßgartenbrunnen

Autenrieder Schloßgartenbrunnen

Ichenhausen-Autenried

Avanus-Mineralbrunnen

Avanus-Mineralbrunnen

Belm

Azur

Azur Quelle Ortelsdorf

Lichtenau

Azur

Azur-Quelle

Bad Vilbel

Bad Brambacher Mineralquelle

Bad Brambacher Mineralquelle

Bad Brambach

Bad Camberger Taunusquelle

Taunusquelle

Bad Camberg-Oberselters

Bad Driburger

Bad Driburger Mineralquelle I

Bad Driburg

Bad Driburger

Brunnen Eichmilde

Bad Driburg

Bad Driburger Bitterwasser

Marcus-Quelle

Bad Driburg

Bad Honnefer Mineralwasser

Fürstenquelle

Bad Honnef

Bad Kissinger

Bad Kissinger

Bad Kissingen

Bad Liebenwerda

Bad Liebenwerda

Bad Liebenwerda

Bad Liebenzeller

Bad Liebenzeller

Bad Liebenzell

Bad Nauheimer

Bad Nauheimer

Friedberg-Dorheim

Bad Nauheimer Ur-Quelle

Bad Nauheimer Urquelle

Friedberg-Dorheim

Bad Niedernauer Römer-Sprudel

Bad Niedernauer Römer-Sprudel

Rottenburg am Neckar-Bad Niedernau

Bad Nieratz-Quelle

Bad Nieratz-Quelle

Wangen im Allgäu

Bad Pyrmonter

Bad Pyrmonter

Bad Pyrmont

Bad Rappenauer Urquelle

Bad Rappenauer Urquelle

Bad Rappenau-Bonfeld

Bad Salzschlirfer Mineralwasser

Retzmann-Brunnen

Bad Salzschlirf

Bad Suderoder Mineralbrunnen

Bad Suderoder Mineralbrunnen

Bad Suderode

Bad Vilbeler Hermanns Quelle

Bad Vilbeler Hermanns Quelle

Bad Vilbel

Bad Vilbeler UrQuelle

Bad Vilbeler UrQuelle

Bad Vilbel

Bad Windsheimer Urquelle

Bad Windsheimer Urquelle

Bad Windsheim

Badnerland-Quelle

Badnerland-Quelle

Bad Peterstal-Griesbach

Badquelle

Badquelle

Neuenburg-Steinenstadt

Balduin Quelle

Balduin-Quelle

Dreis-Brück

Baldus Quelle

Baldus-Quelle

Löhnberg

Barbarossa-Brunnen

Barbarossa-Brunnen

Sinzig

Baron von Westfalen

Waldborn

Horn-Bad-Meinberg

Baruther Johannesbrunnen

Baruther Johannesbrunnen

Baruth/Mark

Basinus

Bonaris Quelle

Neustadt an der Aisch

Basinus

Sinus-Quelle

Eilenburg

Basinus

Krönungsquelle

Bad Windsheim

Bavaria Quelle

Bavaria Quelle

Utting am Ammersee

BellAir

BellAir-Quelle

Bad Liebenzell

Bellaqua

Franziskusquelle

Bad Peterstal

Bellaqua-Quelle

Bellaqua-Quelle

Schwollen

Bellaris-Quelle

Bellaris-Quelle

Bellheim/Pfalz

Berg Quelle

Berg Quelle

Thalfang

Bergische Waldquelle

Bergische Waldquelle

Haan

Bernadett-Brunnen

Bernadett-Brunnen

Ingolstadt

Biberacher Mineralwasser

Biberacher Mineralquelle

Heilbronn am Neckar

Bietzener Wiesen

Bietzener Wiesen

Merzig

Billetalquelle

Billetalquelle

Reinbek

Bios

Bios Quelle

Stralsund

Birgy

Teuto-Quelle

Bielefeld

Bischofsquelle

Bischofsquelle

Dodow

Biskirchener Karlssprudel

Biskirchener Karlssprudel

Leun-Biskirchen

Bissinger Auerquelle

Aquabella und Auerquelle

Bissingen/Schwaben

Black Forest

Hansjakob-Quelle

Bad Rippoldsau

Blankenburger Wiesenquell

Blankenburger Wiesenquell

Blankenburg/Harz

Bonatur

Gesteinsquelle

Bielefeld

Bonatur

Felsenquelle

Hecklingen-Gänsefurth

Bonatur

Tiefenquelle

Bielefeld

Bonwa Mineralwasser

Bonwa

Bad Rappenau-Bonfeld

Borna

Borna

Bochum

Brandenburger Felsenquelle

Brandenburger Felsenquelle

Wiesenburg/Mark

Brandenburger Kurfürst-Quelle

Brandenburger Kurfürst-Quelle

Wiesenburg/Mark

Brandenburger Quell

Brandenburger Quell

Diedersdorf

Brandenburger Urstromquelle

Brandenburger Urstromquelle

Baruth/Mark

Brandenburger Waldquelle

Brandenburger Waldquelle

Wiesenburg/Mark

Breisgauer Mineralwasser

Breisgauer Mineralquelle

Neuenburg-Steinenstadt

Brillant

Brillant

Schwollen

Brillant Quelle

Brillant-Quelle

Thalfang

Brohler

Burgbrohlerquelle+C66

Burgbrohl

Brohler Classic

Karlsquelle

Brohl-Lützing

Brohler high light

Quelle Acht

Brohl-Lützing

Brunnthaler

Brunnthaler

Burgheim

Buchhorn Quelle

Buchhorn Quelle

Eberstadt-Buchhorn

Burgenperle

Burgenperle-Quelle

Reutlingen-Rommelsbach

Bürgerfels-Quelle

Bürgerfels-Quelle

Moers

Burg-Quelle

Burg-Quelle