Reference of the decision (2)

Date of decision

Substance name

Holder of the authorisation

Authorisation number

Authorised use

Date of expiry of review period

Reasons for the decision

C(2023) 7574

15 November 2023

4-(1,1,3,3-tetramethylbutyl)phenol, ethoxylated (‘4-tert-OPnEO’)

EC No.-; CAS No.-

4-Nonylphenol, branched and linear, ethoxylated (4-NPnEO)

EC No.-; CAS No.-

Phadia GmbH,

Munzinger Strasse 7, 79111 Freiburg, Germany

Thermo Fisher Scientific Baltics UAB V.A.Graiciuno 8, LT-02241 Vilnius, Lithuania

REACH/23/32/0

REACH/23/32/1

4-tert-OPnEO as components of buffer solutions with the following purposes: (1) production of purified proteins (to achieve cell extraction, chromatographic purification and solvent exchange); and (2) in-process and final quality control testing; intended for use as laboratory reagents in scientific research and development and in vitro diagnostic applications

4 January 2033

In accordance with Article 60(4) of Regulation (EC) No 1907/2006, the socio-economic benefits outweigh the risk to human health and the environment from the use of the substance and there are no suitable alternative substances or technologies.

Thermo Fisher Scientific Baltics UAB V.A.Graiciuno 8, LT-02241 Vilnius, Lithuania

REACH/23/32/2

4-NPnEO as components of buffer solutions with the following purposes: (1) production of purified proteins (to achieve cell extraction, chromatographic purification and solvent exchange); and (2) in-process and final quality control testing; intended for use as laboratory reagents in scientific research and development and in vitro diagnostic applications

Phadia GmbH,

Munzinger Strasse 7, 79111 Freiburg, Germany

Brahms GmbH, Neuendorfstrasse 25, 16761 Hennigsdorf, Germany

REACH/23/32/3

REACH/23/32/4

4-tert-OPnEO in coating thyroid stimulating hormone receptor onto articles used as components of in vitro diagnostic reagent systems