—

annul in its entirety ECHA Decision D(2025)7771-DC of 11 December 2025, identifying n-hexane (EC No. 203-777-6; CAS No. 110-54-3) as a substance of very high concern on the basis of specific target organ toxicity after repeated exposure (nervous system) pursuant to Article 57(f) – human health – of Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) (1);

—

order the removal of n-hexane from the Candidate List published on 4 February 2026; and

—

order ECHA to pay the costs of the proceedings, including the applicants’ legal costs, pursuant to Article 134 of the Rules of Procedure of the General Court.

1.

First plea in law, alleging a manifest error of assessment.

2.

Second plea in law, alleging infringement of the principle of proportionality: the existence of adequate OELs and occupational risk management measures together with a detailed Chemical Safety Report render the substance of very high concern (SVHC) listing disproportionate.

3.

Third plea in law, alleging infringement of the principle of legal certainty: absence of precedent for reversible, occupational neurotoxicity under Article 57(f) of REACH.

4.

Fourth plea in law, alleging infringement of Article 1 of REACH and misuse of powers.

5.

Fifth plea in law, alleging a breach of essential procedural requirements: inadequate reasoning under Article 296 TFEU.